Best Way to Backup Windows 2008 R2 server

What is the best way of backing up Windows 2008 R2 server using Backup Exec 2010 R3? The server is running on Dell PowerEdge 2950 (it is not a virtual server). The server has couple of harddrive partitions. C:\ drive has OS. D:\ and E:\ drive has data.

Let say I got a blue screen and server is no longer bootable. How should I setup a backup job so I can completely restore the server without re-installing the OS and without losing any data on the server?

Please provide me with step by step detials with how can I setup a backup job and how can I restore in case of blue screen.

Thanks in advance.